He was born in Cleveland, Ohio, and received his Bachelor of Science degree at the University of Kentucky in 1941 and his Doctor of Philosophy degree from the California Institute of Technology in 1946.
From 1946 to 1959 he taught at the University of Minnesota, becoming a professor of chemistry at Harvard University in 1959.
He deduced the molecular structure of boranes using X-ray crystal diffraction analysis in the 1950s and developed theories to explain their bonds. Later he applied the same methods to related problems, including the structure of carboranes on which he directed the research of future Nobel Prize winner Roald Hoffmann.
He was elected to the National Academy of Sciences in 1961, and awarded the Nobel Prize in Chemistry in 1976.