His most famous building is his own house, made entirely of glass and steel. This glass house (1949) may not have had much going for it in terms of livability, but was a high-water mark for modernist architecture. He also designed the 1958 Seagram Building in New York (with Ludwig Mies van der Rohe), one of the first glass box skyscrapers.
Johnson was awarded the first Pritzker Prize in architecture in 1979.