A series of wars for control over the States of Italy, mainly invlving France and Spain, but also involving most other European states, and the imprisonment for several months of Pope Clement VII.
Started with the plotting of Ludovico Sforza of Milan a.k.a. "Ludovico il Moro" encouraging French involvement.
Finally ended with the Treaty of Cateau-Cambrésis, leaving Spain as the dominant power in the region.
